Anti-CHRNA7 antibodies are used in the immunodetection of the protein cholinergic receptor nicotinic alpha 7 subunit. In humans, the canonical protein has a reported length of 502 amino acid residues and a mass of 56.4 kDa. Its subcellular localization is in the cell membrane. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Ligand-gated ion channel (TC 1.A.9) protein family, CHRNA7 is known to be involved with the transport of ions and the regulation of intracellular calcium. Post-translational modifications have been described, including glycosylation.
The CHRNA7 marker can be used to identify Gray Matter Interneurons.* Synonyms for this target antigen include NACHRA7, neuronal acetylcholine receptor subunit alpha-7, a7 nicotinic acetylcholine receptor, alpha 7 neuronal nicotinic acetylcholine receptor, and CHRNA7-2. CHRNA7 gene orthologs have been reported in the mouse, rat, zebrafish and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4