Anti-HERC1 antibodies are used in the immunodetection of the protein HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. In humans, the canonical protein has a reported length of 4861 amino acid residues and a mass of 532.2 kDa. Its subcellular localization is in the membrane, Golgi, and cytoplasm. It is widely expressed across many tissue types. HERC1 is known to be involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Synonyms for this target antigen include p532, p619, probable E3 ubiquitin-protein ligase HERC1, HECT domain and RCC1-like domain-containing protein 1, and MDFPMR. HERC1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of HERC1 antibodies have been mentioned in research publications and have associated citations. Immunofluorescence is a widely used application for these antibodies. Immunocytochemistry and Immunohistochemistry are also common applications.