Anti-AAGAB antibodies are used in the immunodetection of the protein alpha and gamma adaptin binding protein. In humans, the canonical protein has a reported length of 315 amino acid residues and a mass of 34.6 kDa. Its subcellular localization is in the cytoplasm. Up to 2 different isoforms have been reported for this protein. It is reported to be widely expressed including in skin and keratinocytes, with highest levels in adrenal gland, rectum and thymus. AAGAB is suspected to be involved in endocytic recycling of growth factor receptors such as EGFR. The AAGAB gene has been associated with the disease, Keratoderma. Synonyms for this target antigen include alpha- and gamma-adaptin-binding protein p34 and punctate palmoplantar keratoderma type I. AAGAB gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of AAGAB antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.