Anti-MICA antibodies are used in the immunodetection of the protein MHC class I polypeptide-related sequence A. In humans, the canonical protein has a reported length of 383 amino acid residues and a mass of 42.9 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is reported to be widely expressed with the exception of the central nervous system where it is absent. A member of the MHC class I protein family, MICA is known to be involved with viral immune response and DNA damage pathways. The MICA gene has been associated with the disease, Psoriasis. Synonyms for this target antigen include MHC class I chain-related protein A, MHC class I related chain A, MHC class I related sequence A, major histocompatibility complex class I chain-related protein A, and HLA class I antigen. Over 290 citations in the literature describe the use of MICA antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Flow Cytometry, and Immunohistochemistry are also common applications.