Anti-ZNF281 antibodies are used in the immunodetection of the protein zinc finger protein 281. In humans, the canonical protein has a reported length of 895 amino acid residues and a mass of 96.9 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of a the Krueppel C2H2-type zinc-finger protein family, ZNF281 is reported to be a transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Synonyms for this target antigen include ZBP-99, ZBP99, ZNP-99, GC-box-binding zinc finger protein 1, ZNP-99 transcription factor, and GZP1.