Anti-CLCNKB antibodies are used in the immunodetection of the protein chloride voltage-gated channel Kb. In humans, the canonical protein has a reported length of 687 amino acid residues and a mass of 75.4 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in the kidney. A member of the Chloride channel (TC 2.A.49) protein family, CLCNKB is known to be involved with the transport of ions. Post-translational modifications have been described, including glycosylation. The CLCNKB marker can be used to identify Pulmonary Ionocytes.* Synonyms for this target antigen include ClC-K2, ClC-Kb, chloride channel protein ClC-Kb, chloride channel, kidney, B, chloride channel, voltage-sensitive Kb, and CLCKB. CLCNKB gene orthologs have been reported in the mouse, rat and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4