Anti-HIGD2A antibodies are used in the immunodetection of the protein HIG1 hypoxia inducible domain family member 2A. In humans, the canonical protein has a reported length of 106 amino acid residues and a mass of 11.5 kDa. Its subcellular localization is in the mitochondria. HIGD2A is reported to be a proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Synonyms for this target antigen include HIG1 domain family, member 2A, RCF1 homolog B, and HIG1 domain family member 2A, mitochondrial. HIGD2A gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of HIGD2A antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, and Immunofluorescence are also common applications.