Anti-L2HGDH antibodies are used in the immunodetection of the protein L-2-hydroxyglutarate dehydrogenase. In humans, the canonical protein has a reported length of 463 amino acid residues and a mass of 50.3 kDa. Its subcellular localization is in the mitochondria. Up to 2 different isoforms have been reported for this protein. It is widely expressed across many tissue types. A member of the L2HGDH protein family, L2HGDH is known to be involved with metabolic processes. The L2HGDH gene has been associated with the disease, L-2-hydroxyglutaric aciduria. Synonyms for this target antigen include 2-hydroxyglutarate dehydrogenase, L-alpha-hydroxyglutarate dehydrogenase, alpha-hydroxyglutarate oxidoreductase, alpha-ketoglutarate reductase, and L-2-hydroxyglutarate dehydrogenase, mitochondrial. L2HGDH gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of L2HGDH antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.