Anti-ZP1 antibodies are used in the immunodetection of the protein zona pellucida glycoprotein 1. In humans, the canonical protein has a reported length of 638 amino acid residues and a mass of 70 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in oocytes. A member of the ZP domain protein family, ZP1 is a known component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. Post-translational modifications have been described, including O-glycosylation and protein cleavage. Synonyms for this target antigen include OOMD, OOMD1, OZEMA1, ZPB1, zona pellucida sperm-binding protein 1, and HEL163. ZP1 gene orthologs have been reported in the mouse, rat, chimpanzee and chicken species. Some ZP1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.