Anti-GLDC antibodies are used in the immunodetection of the protein glycine decarboxylase. In humans, the canonical protein has a reported length of 1020 amino acid residues and a mass of 112.7 kDa. Its subcellular localization is in the mitochondria. It is notably expressed in many tissues, such as the cerebellum and colon. It is a member of the GcvP protein family. GLDC is also used as a cellular marker for characterizing astrocytes. Synonyms for this target antigen include GCSP, HYGN1, glycine dehydrogenase (decarboxylating), mitochondrial, glycine cleavage system protein P, and GCE. GLDC gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.