Anti-CDH12 antibodies are used in the immunodetection of the protein cadherin 12. In humans, the canonical protein has a reported length of 794 amino acid residues and a mass of 88.3 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the brain. CDH12 is known to be involved with cell adhesion. Post-translational modifications have been described, including glycosylation.
The CDH12 marker can be used to identify Hypothalamus Splatter Neurons.* Synonyms for this target antigen include Br-cadherin, N-cadherin 2, brain-cadherin, cadherin, neural type, 2, neural type cadherin 2, and CDHB. CDH12 gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. A number of CDH12 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4