Anti-fibrinogen alpha chain antibodies are used for the immunodetection of the protein encoded by the FGA gene. In humans, the canonical protein has a reported length of 866 amino acid residues and a mass of 95 kDa. It is known to be a secreted protein. Alternative splicing is reported to yield 2 different isoforms for this protein. It is notably expressed in blood plasma. It is noted to be involved in adaptive immune responses and cell matrix adhesion. Post-translational modifications have been described, including O-glycosylation, N-glycosylation and phosphorylation. The gene encoding this protein is implicated in Congenital afibrinogenemia. Other names for this target antigen include Fib2 and fibrinogen, A alpha polypeptide. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 100 citations in the literature describe the use of fibrinogen alpha chain antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.