Anti-HM74 antibodies are used in antigen-specific immunodetection in biological samples. The target HM74 is a known alias name of the protein hydroxycarboxylic acid receptor 3, encoded by the HCAR3 gene in humans. This 387-amino acid residue protein is a known receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. It is localized to the cell membrane of the cell. It is reported to be expressed in soft tissue, nasopharynx, lymph node, lung, and bone marrow. Other synonyms for HM74 include GPR109B, GPR109B, and HCA3.