Anti-VWCE antibodies are used in the immunodetection of the protein von Willebrand factor C and EGF domains. In humans, the canonical protein has a reported length of 955 amino acid residues and a mass of 99.9 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the liver. VWCE is believed to be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include HBV X protein up-regulated gene 11 protein, HBxAg up-regulated gene 11 protein, and von Willebrand factor C and EGF domain-containing protein. VWCE gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some VWCE antibodies may have been used in research and have associated citations. Immunohistochemistry is a widely used application for these antibodies. Immunocytochemistry and Immunofluorescence are also common applications.