Anti-ATP10A antibodies are used in the immunodetection of the protein ATPase phospholipid transporting 10A (putative). In humans, the canonical protein has a reported length of 1499 amino acid residues and a mass of 167.7 kDa. Its subcellular localization is in the ER and cell membrane. Up to 2 different isoforms have been reported for this protein. It is found to be widely expressed, with highest levels in the kidney, followed by lung, brain, prostate, testis, ovary and small intestine. A member of the Cation transport ATPase (P-type) (TC 3.A.3) protein family, ATP10A is reported to be a catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane.
The ATP10A marker can be used to identify Cerebral Cortex Neurons, Deep-Layer Intratelencephalic Neurons, Gray Matter CA1-3 Neurons, and Hippocampal Gyrus CA4 Neurons.* Synonyms for this target antigen include ATPase type IV, phospholipid transporting (P-type), ATPase, Class V, type 10C, ATPase, class V, type 10A, P4-ATPase flippase complex alpha subunit ATP10A, and phospholipid-transporting ATPase VA. These ATP10A antibodies are widely used in Western Blot experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4