Anti-NXN antibodies are used in the immunodetection of the protein nucleoredoxin. In humans, the canonical protein has a reported length of 435 amino acid residues and a mass of 48.4 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the colon and kidney. A member of the Nucleoredoxin protein family, NXN is known to function as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. The NXN gene has been associated with the disease, Robinow syndrome. Synonyms for this target antigen include nucleoredoxin 1. NXN gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of NXN antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.