Anti-HPGDS antibodies are used in the immunodetection of the protein hematopoietic prostaglandin D synthase. In humans, the canonical protein has a reported length of 199 amino acid residues and a mass of 23.3 kDa. Its subcellular localization is in the cytoplasm. It is reported to be expressed in a number of megakaryocytic cell lines but not in platelets. A member of the Sigma protein family, HPGDS is reported to be a bifunctional enzyme, which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates.
The HPGDS marker can be used to identify Eosinophils, Mast Cells, Pancreatic Ductal Cells, and Hematopoetic Stem Cells.* Synonyms for this target antigen include GSTS1, GSTS1-1, PGD2, PGDS, GST class-sigma, and GSTS. HPGDS gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4