Anti-ADAM28 antibodies are used in the immunodetection of the protein ADAM metallopeptidase domain 28. In humans, the canonical protein has a reported length of 775 amino acid residues and a mass of 87.1 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. ADAM28 is believed to play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L.
The ADAM28 marker can be used to identify Unswitched Memory B Cells and Class Switched Memory B Cells.* Synonyms for this target antigen include MDCL, eMDC II, eMDCII, disintegrin and metalloproteinase domain-containing protein 28, and MDC-L. ADAM28 gene orthologs have been reported in the mouse, rat, chimpanzee and chicken species. A number of ADAM28 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4