Anti-TNFRSF25 antibodies are used in the immunodetection of the protein TNF receptor superfamily member 25. In humans, the canonical protein has a reported length of 417 amino acid residues and a mass of 45.4 kDa. Up to 12 different isoforms have been reported for this protein. It is found to be highly expressed in thymocytes and lymphocytes. TNFRSF25 is a known receptor for TNFSF12/APO3L/TWEAK. Post-translational modifications have been described, including glycosylation. The TNFRSF25 marker can be used to identify Regulatory T Cells.* Synonyms for this target antigen include DDR3, DR3, GEF720, LARD, PLEKHG5, TNFRSF12, TR3, and APO-3. TNFRSF25 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 70 citations in the literature describe the use of TNFRSF25 antibodies in research. These antibodies are most commonly used in Western Blot experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4