Anti-profilin 2 antibodies are used in the immunodetection of the protein encoded by the PFN2 gene. In humans, the canonical protein has a reported length of 140 amino acid residues and a mass of 15 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be highly expressed in the brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. A member of the Profilin protein family, it is known to bind to actin and affects the structure of the cytoskeleton. Other names for this target antigen include PFL, profilin II, and D3S1319E.