Anti-SPAST antibodies are used in the immunodetection of the protein spastin. In humans, the canonical protein has a reported length of 616 amino acid residues and a mass of 67.2 kDa. It is reported to be expressed in the brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. A member of the AAA ATPase protein family, SPAST is known to be involved with neuronal development and Golgi transport. The SPAST gene has been associated with the disease, Spastic paraplegia. Synonyms for this target antigen include FSP2, SPG4, spastic paraplegia 4 (autosomal dominant; spastin), spastic paraplegia 4 protein, and ADPSP. SPAST gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of SPAST antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.