Anti-TPMT antibodies are used in the immunodetection of the protein thiopurine S-methyltransferase. In humans, the canonical protein has a reported length of 245 amino acid residues and a mass of 28.2 kDa. Its subcellular localization is in the cytoplasm. It is notably widely expressed in many tissue types. A member of the TPMT protein family, TPMT is known to catalyze the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor. Synonyms for this target antigen include TPMTD and S-adenosyl-L-methionine:thiopurine S-methyltransferase. TPMT gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some TPMT antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.