Anti-PIGO antibodies are used in the immunodetection of the protein phosphatidylinositol glycan anchor biosynthesis class O. In humans, the canonical protein has a reported length of 1089 amino acid residues and a mass of 118.7 kDa. Its subcellular localization is in the ER. Up to 2 different isoforms have been reported for this protein. It is a member of the PIGG/PIGN/PIGO protein family. Post-translational modifications have been described, including glycosylation. The PIGO gene has been associated with the disease, Hyperphosphatasia with impaired intellectual development syndrome. Synonyms for this target antigen include GPI ethanolamine phosphate transferase 3 and phosphatidylinositol-glycan biosynthesis class O protein. PIGO gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some PIGO antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.