Anti-Reticulon 4 antibodies are used for the immunodetection of the protein encoded by the RTN4 gene. In humans, the canonical protein has a reported length of 1192 amino acid residues and a mass of 129.9 kDa. Its subcellular localization is in the ER and cell membrane. Alternative splicing is reported to yield 6 different isoforms for this protein. It is known to be required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. Other names for this target antigen include My043 protein, foocen, neurite growth inhibitor 220, neurite outgrowth inhibitor, neuroendocrine-specific protein C homolog, and Human NogoA. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 90 citations in the literature describe the use of Reticulon 4 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.