Anti-PTPN7 antibodies are used in the immunodetection of the protein protein tyrosine phosphatase non-receptor type 7. In humans, the canonical protein has a reported length of 360 amino acid residues and a mass of 40.5 kDa. Its subcellular localization is in the cytoplasm. Up to 3 different isoforms have been reported for this protein. It is found to be preferentially expressed in thymus and spleen. A member of the Protein-tyrosine phosphatase protein family, PTPN7 is reported to be a protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Post-translational modifications have been described, including phosphorylation. The PTPN7 marker can be used to identify CD8?a Thymocytes.* Synonyms for this target antigen include HEPTP, LPTP, PTPNI, tyrosine-protein phosphatase non-receptor type 7, and BPTP-4. PTPN7 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4