Anti-RC3H2 antibodies are used in the immunodetection of the protein ring finger and CCCH-type domains 2. In humans, the canonical protein has a reported length of 1191 amino acid residues and a mass of 131.7 kDa. Its subcellular localization is in the cytoplasm. Up to 6 different isoforms have been reported for this protein. It is reported to be expressed in spleen, testis, ovary and small intestine. RC3H2 is reported to be a post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Post-translational modifications have been described, including protein cleavage. Synonyms for this target antigen include RNF164, roquin-2, RING finger protein 164, RING-type E3 ubiquitin transferase Roquin-2, and MNAB. RC3H2 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. Some RC3H2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.