Anti-PTH2R antibodies are used in the immunodetection of the protein parathyroid hormone 2 receptor. In humans, the canonical protein has a reported length of 550 amino acid residues and a mass of 62.2 kDa. Its subcellular localization is in the cell membrane. It is noted to be expressed abundantly in the brain and pancreas. A member of the G-protein coupled receptor 2 protein family, Pth2r is a specific receptor for parathyroid hormone. Post-translational modifications have been described, including glycosylation. The PTH2R marker can be used to identify Eccentric Medium Spiny Neurons, Thalamic Excitatory Neurons, and Amygdala Excitatory Neurons.* Synonyms for this target antigen include PTH2 receptor, parathyroid hormone receptor 2, and PTHR2. PTH2R gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. Western Blot is the most common application for the Pth2r antibodies listed below. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4