Anti-SPCS1 antibodies are used in the immunodetection of the protein signal peptidase complex subunit 1. In humans, the canonical protein has a reported length of 169 amino acid residues and a mass of 18.3 kDa. Its subcellular localization is in the ER. It is notably widely expressed in many tissue types. A member of the SPCS1 protein family, SPCS1 is a known component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include SPC1, SPC12, YJR010C-A, SPase 12 kDa subunit, microsomal signal peptidase 12 kDa subunit, and HSPC033. SPCS1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some SPCS1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.