Anti-SCG2 antibodies are used in the immunodetection of the protein secretogranin II. In humans, the canonical protein has a reported length of 617 amino acid residues and a mass of 70.9 kDa. It has been described to be a secreted protein. It is notably expressed in many tissues, such as the adrenal gland and colon. A member of the Chromogranin/secretogranin protein family, SCG2 is reported to be a neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. Post-translational modifications have been described, including O-glycosylation.
The SCG2 marker can be used to identify Prostate Gland Endocrine-Paracrine Cells.* Synonyms for this target antigen include EM66, SN, SgII, secretogranin-2, chromogranin-C, secretoneurin, and CHGC. SCG2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of SCG2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4