Anti-NXPH2 antibodies are used in the immunodetection of the protein neurexophilin 2. In humans, the canonical protein has a reported length of 264 amino acid residues and a mass of 29.9 kDa. It has been described to be a secreted protein. It is reported to be expressed in the brain and kidney. A member of the Neurexophilin protein family, NXPH2 is believed to be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Post-translational modifications have been described, including protein cleavage and glycosylation.
The NXPH2 marker can be used to identify Deep-Layer Near-Projecting Neurons, Gray Matter Splatter Neurons, and Type A Connecting Tubule Intercalated Cells.* Synonyms for this target antigen include NPH2. NXPH2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Western Blot is the most common application for the NXPH2 antibodies listed below. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4