Anti-NSMCE2 antibodies are used in the immunodetection of the protein NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. In humans, the canonical protein has a reported length of 247 amino acid residues and a mass of 27.9 kDa. Its subcellular localization is in the nucleus. It is notably widely expressed in many tissue types. A member of the NSE2 protein family, NSMCE2 is known to be involved with the cell cycle. Post-translational modifications have been described, including sumoylation. The NSMCE2 gene has been associated with the disease, Seckel syndrome. Synonyms for this target antigen include E3 SUMO-protein transferase NSE2, NSMCE2/PVT1 fusion, PVT1/NSMCE2 fusion, methyl methanesulfonate sensitivity gene 21, and E3 SUMO-protein ligase NSE2. NSMCE2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some NSMCE2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Flow Cytometry, and Immunofluorescence are also common applications.