Anti-PCDH11X antibodies are used in the immunodetection of the protein protocadherin 11 X-linked. In humans, the canonical protein has a reported length of 1347 amino acid residues and a mass of 147.6 kDa. Its subcellular localization is in the cell membrane. Up to 8 different isoforms have been reported for this protein. It is noted to be expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). PCDH11X is known to be involved with cell adhesion. Post-translational modifications have been described, including glycosylation.
The PCDH11X marker can be used to identify Eccentric Medium Spiny Neurons.* Synonyms for this target antigen include PCDH-Y, PCDH11, PCDH11Y, PCDH22, PCDHX, PPP1R119, Protocadherin on the Y chromosome, and PCDH-X. PCDH11X gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some PCDH11X antibodies may have been used in research and have associated citations. Immunofluorescence is a widely used application for these antibodies. ELISA, Western Blot, Immunocytochemistry, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4