Anti-HLA-DOB antibodies are used in the immunodetection of the protein major histocompatibility complex, class II, DO beta. In humans, the canonical protein has a reported length of 273 amino acid residues and a mass of 30.8 kDa. Its subcellular localization is in the endosome and lysosomes. It is notably expressed in the tonsil, testis, spleen, lymph node, and appendix. A member of the MHC class II protein family, HLA-DOB is known to be involved with adaptive immune responses. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include HLA_DOB, HLA class II histocompatibility antigen, DO beta chain, MHC class II antigen DOB, and DOB. HLA-DOB gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Some HLA-DOB antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.