Anti-MIB2 antibodies are used in the immunodetection of the protein MIB E3 ubiquitin protein ligase 2. In humans, the canonical protein has a reported length of 955 amino acid residues and a mass of 103.7 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 9 different isoforms for this protein. It is reported to be expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney. Among its functions, MIB2 is involved with the Notch signaling pathway and NF-kappaB signaling pathways. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include RING-type E3 ubiquitin transferase MIB2, mind bomb homolog 2, mindbomb E3 ubiquitin protein ligase 2, mindbomb homolog 2, novel zinc finger protein, and E3 ubiquitin-protein ligase MIB2.