Anti-HCN1 antibodies are used in the immunodetection of the protein hyperpolarization activated cyclic nucleotide gated potassium channel 1. In humans, the canonical protein has a reported length of 890 amino acid residues and a mass of 98.8 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in the thyroid gland, skin, retina, cerebral cortex, and cerebellum. A member of the Potassium channel HCN protein family, HCN1 is known to be involved with potassium ion transport. Post-translational modifications have been described, including glycosylation. The HCN1 gene has been associated with the disease, Developmental and epileptic encephalopathy. Synonyms for this target antigen include brain cyclic nucleotide-gated channel 1, and potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1. HCN1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 90 citations in the literature describe the use of HCN1 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.