Anti-ST8SIA6 antibodies are used in the immunodetection of the protein ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6. In humans, the canonical protein has a reported length of 398 amino acid residues and a mass of 44.8 kDa. Its subcellular localization is in the Golgi. A member of the Glycosyltransferase 29 protein family, ST8SIA6 is a reported alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. Post-translational modifications have been described, including glycosylation.
The ST8SIA6 marker can be used to identify Gray Matter Splatter Neurons and Thalamic Excitatory Neurons.* Synonyms for this target antigen include ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 6, sialyltransferase 8F (alpha-2, 8-sialyltransferase), sialyltransferase St8Sia VI, and alpha-2,8-sialyltransferase 8F. ST8SIA6 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Western Blot is a widely used application for the ST8SIA6 antibodies listed below. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4