Anti-neuropeptide Y antibodies are used for the immunodetection of the protein encoded by the NPY gene. In humans, the canonical protein has a reported length of 97 amino acid residues and a mass of 10.9 kDa. Its subcellular localization is in the cytoplasmic vesicles and is secreted. A member of the NPY protein family, it is known to be involved with pathways of aging and nervous system development. Post-translational modifications have been described, including protein cleavage.
The neuropeptide Y marker can be used to characterize Brain Splatter Neurons, Gray Matter MGE Interneurons, and Dorsal Excitatory Neurons.* Other names for this target antigen include pro-neuropeptide Y, prepro-neuropeptide Y, and PYY4. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 310 citations in the literature describe the use of neuropeptide Y antibodies in research. Immunohistochemistry is a widely used application for these antibodies. ELISA and Western Blot are also common applications.
*HuBMAP Human Reference Atlas v1.4