Anti-TRPM5 antibodies are used in the immunodetection of the protein transient receptor potential cation channel subfamily M member 5. In humans, the canonical protein has a reported length of 1165 amino acid residues and a mass of 131.5 kDa. Its subcellular localization is in the cell membrane. Up to 3 different isoforms have been reported for this protein. It is reported to be highly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. A member of the Transient receptor (TC 1.A.4) protein family, TRPM5 is known to be involved with the transport of ions.
The TRPM5 marker can be used to identify Intestinal Tuft Cells and Tuft Cells.* Synonyms for this target antigen include MTR1, MLSN1 and TRP-related, MLSN1- and TRP-related gene 1 protein, long transient receptor potential channel 5, and LTRPC5. TRPM5 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species. A number of TRPM5 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4