Anti-NPPA antibodies are used in the immunodetection of the protein natriuretic peptide A. In humans, the canonical protein has a reported length of 151 amino acid residues and a mass of 16.4 kDa. It has been described to be a secreted protein. It is notably expressed in the heart muscle. A member of the Natriuretic peptide protein family, NPPA is known to be involved with the regulation of Wnt signaling pathways. Post-translational modifications have been described, including protein cleavage and phosphorylation. The NPPA marker can be used to identify Cardiomyocytes.* Synonyms for this target antigen include ANP, ATFB6, ATRST2, CDD, CDD-ANF, CDP, PND, and ANF. NPPA gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. Over 140 citations in the literature describe the use of Nppa antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4