Anti-MT-ND1 antibodies are used in the immunodetection of the protein mitochondrially encoded NADH dehydrogenase 1. In humans, the canonical protein has a reported length of 318 amino acid residues and a mass of 35.7 kDa. Its subcellular localization is in the mitochondria. It is notably expressed in many tissues, such as the heart muscle and kidney. A member of the Complex I subunit 1 protein family, MT-ND1 is reported to be a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. The MT-ND1 gene has been associated with the disease, Leber hereditary optic neuropathy. Synonyms for this target antigen include MTND1 and NADH dehydrogenase subunit 1.