Anti-TMIGD2 antibodies are used in the immunodetection of the protein transmembrane and immunoglobulin domain containing 2. In humans, the canonical protein has a reported length of 282 amino acid residues and a mass of 30.7 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the colon, stomach, and cerebellum. TMIGD2 is reported to play a role in cell-cell interaction, cell migration, and angiogenesis. Post-translational modifications have been described, including N-glycosylation.
The TMIGD2 marker can be used to identify Human Group 3 Innate Lymphoid Cells.* Synonyms for this target antigen include CD28 homolog, CD28 homologue, immunoglobulin and proline-rich receptor 1, immunoglobulin-containing and proline-rich receptor 1, and transmembrane and immunoglobulin domain-containing protein 2. TMIGD2 gene orthologs have been reported in the bovine, chimpanzee and chicken species. Flow Cytometry is the most common application for the TMIGD2 antibodies listed below. ELISA, Western Blot, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4