Anti-HYAL2 antibodies are used in the immunodetection of the protein hyaluronidase 2. In humans, the canonical protein has a reported length of 473 amino acid residues and a mass of 53.9 kDa. Its subcellular localization is in the cell membrane. It is widely expressed across many tissue types. A member of the Glycosyl hydrolase 56 protein family, HYAL2 is known to be involved with carbohydrate metabolism and homeostasis and cartilage development. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include PH-20 homolog, PH20 homolog, hyaluronoglucosaminidase 2, lung carcinoma protein 2, lysosomal hyaluronidase, and LUCA2. HYAL2 gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. A number of HYAL2 antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA and Western Blot are also common applications.