Anti-PTGS1 antibodies are used in the immunodetection of the protein prostaglandin-endoperoxide synthase 1. In humans, the canonical protein has a reported length of 599 amino acid residues and a mass of 68.7 kDa. Its subcellular localization is in the ER and membrane. Up to 6 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Prostaglandin G/H synthase protein family, PTGS1 is known to be involved with the regulation of cell proliferation and the response to oxidative stress. Post-translational modifications have been described, including glycosylation.
The PTGS1 marker can be used to identify Intestinal Tuft Cells.* Synonyms for this target antigen include COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, and COX1. PTGS1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 230 citations in the literature describe the use of PTGS1 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4