Anti-ITPR1 antibodies are used in the immunodetection of the protein inositol 1,4,5-trisphosphate receptor type 1. In humans, the canonical protein has a reported length of 2758 amino acid residues and a mass of 313.9 kDa. Its subcellular localization is in the cytoplasmic vesicles, ER, and cytoplasm. Alternative splicing is reported to yield 8 different isoforms for this protein. It is widely expressed across many tissue types. A member of a the InsP3 receptor protein family, ITPR1 is reported to be an intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Post-translational modifications have been described, including glycosylation, ubiquitination, palmitoylation and phosphorylation. Synonyms for this target antigen include CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, and ACV.