Anti-PAPOLA antibodies are used in the immunodetection of the protein poly(A) polymerase alpha. In humans, the canonical protein has a reported length of 745 amino acid residues and a mass of 82.8 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Poly(A) polymerase protein family, PAPOLA is a reported polymerase that creates the 3'-poly(A) tail of mRNA's. Post-translational modifications have been described, including sumoylation, acetylation and phosphorylation. Synonyms for this target antigen include PAP-alpha, polynucleotide adenylyltransferase alpha, and PAP. PAPOLA gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of PAPOLA antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. Western Blot and Immunofluorescence are also common applications.