Anti-GGCX antibodies are used in the immunodetection of the protein gamma-glutamyl carboxylase. In humans, the canonical protein has a reported length of 758 amino acid residues and a mass of 87.6 kDa. Its subcellular localization is in the ER. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Vitamin K-dependent gamma-carboxylase protein family, GGCX is known to mediate the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Synonyms for this target antigen include vitamin K-dependent gamma-carboxylase, peptidyl-glutamate 4-carboxylase, and VKCFD1. GGCX gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. A number of GGCX antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA, Western Blot, Immunocytochemistry, and Immunofluorescence are also common applications.