Anti-FANK1 antibodies are used in the immunodetection of the protein fibronectin type III and ankyrin repeat domains 1. In humans, the canonical protein has a reported length of 345 amino acid residues and a mass of 38.3 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. FANK1 is known to be involved with the regulation of apoptosis and the regulation of transcription. Post-translational modifications have been described, including ubiquitination.
The FANK1 marker can be used to identify Regulatory T Cells.* Synonyms for this target antigen include fibronectin type 3 and ankyrin repeat domains 1, and fibronectin type 3 and ankyrin repeat domains protein 1. FANK1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. Some FANK1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4