Anti-DPYD antibodies are used in the immunodetection of the protein dihydropyrimidine dehydrogenase. In humans, the canonical protein has a reported length of 1025 amino acid residues and a mass of 111.4 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of a the Dihydropyrimidine dehydrogenase protein family, DPYD is known to be involved in pyrimidine base degradation. Synonyms for this target antigen include DHPDHASE, DPD, DYPD, dihydropyrimidine dehydrogenase [NADP(+)], dihydrothymine dehydrogenase, and DHP.