Anti-LGI4 antibodies are used in the immunodetection of the protein leucine rich repeat LGI family member 4. In humans, the canonical protein has a reported length of 537 amino acid residues and a mass of 59.1 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is found to be widely expressed, with highest expression in the brain. LGI4 is known to be a component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity). Post-translational modifications have been described, including glycosylation. The LGI4 gene has been associated with the disease, Arthrogryposis multiplex congenita. Synonyms for this target antigen include leucine-rich glioma-inactivated gene 4, leucine-rich glioma-inactivated protein 4, and LGI1-like protein 3. LGI4 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Some LGI4 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.