Anti-CHD8 antibodies are used in the immunodetection of the protein chromodomain helicase DNA binding protein 8. In humans, the canonical protein has a reported length of 2581 amino acid residues and a mass of 290.5 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of a the SNF2/RAD54 helicase protein family, CHD8 is reported to be a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Post-translational modifications have been described, including sumoylation. Synonyms for this target antigen include axis duplication inhibitor, duplin, helicase with SNF2 domain 1, and ATP-dependent helicase CHD8.